KAJIAN KELUARGA tHALAssEMIA b-HEMOGLOBIN E
نویسندگان
چکیده
منابع مشابه
Hepcidin is suppressed by erythropoiesis in hemoglobin E b-thalassemia and b-thalassemia trait
Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; College of Medicine, Swansea University, Swansea, United Kingdom; University College of London Cancer Institute, Department of Haematology, University College London, United Kingdom; University of Kelaniya, Colombo, Sri Lanka; National Thalassaemia Centre, District Hospital, Kurun...
متن کاملHemoglobin E-beta thalassemia in Uttar Pradesh.
OBJECTIVE To evaluate the molecular make up of hemoglobin E-Beta thalassemia to facilitate diagnosis, genetic counseling and prenatal diagnosis in Uttar Pradesh. DESIGN DNA analysis. SETTING Referred hemolytic anemia cases to Genetics OPD of a tertiary care center. SUBJECTS 21 families of HbE-thalassemia of which 19 were of UP origin. METHODS The patient and obligate carriers in their f...
متن کاملHemoglobin E-beta thalassemia: factors affecting phenotype.
The phenotype of E-beta-thalassemia is affected by several genetic factors. The aim of this study was to analyze severity of E-beta-thalassemia and correlate with HbE, HbF, E/F ratios, beta-mutation and Xmn I polymorphism. Thirty cases of E-beta-thalassemia (23 with childhood onset) were studied. HbE levels were quantitated by HPLC. Xmn1 polymorphism and beta-mutations were studied by PCR-RFLP ...
متن کاملHemoglobin E Levels in Double Heterozygotes of Hemoglobin E and Sea-type Α-thalassemia
Coinheritance of α-thalassemia and hemoglobin E (Hb E) is prevalent in Thailand, where the gene frequencies of thalassemia and hemoglobinopathies are high. Hb E carriers with, concomitant inheritance of α-thalassemia 1 are known to have a lower level of Hb E. In this study, we reviewed the Hb E levels in Hb E carriers, who either had or did not have Southeast Asian (SEA)-type α-thalassemia, in ...
متن کاملAdaptation to anemia in hemoglobin E-ß thalassemia.
Hemoglobin E β thalassemia is the commonest form of severe thalassemia in many Asian countries. Its remarkably variable clinical phenotype presents a major challenge to determining its most appropriate management. In particular, it is not clear why some patients with this condition can develop and function well at very low hemoglobin levels. Here, we demonstrate that patients with hemoglobin Eβ...
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ژورنال
عنوان ژورنال: INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
سال: 2018
ISSN: 2477-4685,0854-4263
DOI: 10.24293/ijcpml.v13i3.911